The Cassandra Crossing

The Cassandra Crossing is a 1976 ItalianBritish disasterthriller film directed by George Pan Cosmatos and starring Richard Harris, Sophia Loren, Martin Sheen, Burt Lancaster, Lee Strasberg, Ava Gardner and O. J. Simpson about an infected Swedish terrorist who plagues a trains passengers as they head to a derelict arch bridge.

The presence of the infected terrorist, and the rerouting of the train, precipitates the second conflict, among passengers on the train they include Dr. Jonathan Chamberlain Richard Harris, a famous neurologist, his exwife Jennifer Rispoli Chamberlain Sophia Loren, and Nicole Dressler Ava Gardner, the wife of a German arms dealer. She is embroiled in an affair with her young companion Robby Navarro Martin Sheen. Navarro is a heroin trafficker being pursued by FBI agent Haley O.J. Simpson, who is traveling undercover as a priest.Mackenzie informs Dr. Chamberlain of the presence of the stowaway, who is found, but attempts to remove the stowaway via a helicopter are unsuccessful because the train enters a tunnel. Chamberlain is also told that the plague has a 60 mortality rate. Mackenzie, however, informs passengers that police have received reports of anarchist bombs placed along the rail line, and that the train will be rerouted to Nuremberg. There the train is sealed with an enclosed oxygen system and a U.S. Army medical team is placed aboard, with the nowdeceased stowaway being placed in a hermeticallysealed coffin. Dr. Chamberlain learns of the risk of the Cassandra Crossing. He also begins to suspect the disease is not as serious as originally thought few of the passengers have become infected and few of those have actually died. He radios MacKenzie suggesting the infected portion of the train be uncoupled and isolated, but MacKenzie has no intention of stopping the train if, as expected, the Cassandra Crossing collapses, it will neatly cover the fact that the U.S has been harbouring germ warfare agents in a neutral country. Passengers on the train work together to stop the train before it reaches the Cassandra Crossing. ........

Source: Wikipedia